<<back

INGREDIENTS:  
Water (S), Niacinamide (L), Glycerin (and) Glyceryl Polyacrylate (M), Glycerin (M), Ascorbyl Glucoside (AO), Glycerin (and) Butylene Glycol (and) Aqua (and) Carbomer (and) Polysorbate 20 (and) Palmitoyl Pentapeptide-3 (L/M), Undecylenoyl Phenylalanine (L), Sodium Hyaluronate (M), Diazolidinyl Urea (P), Methylparaben (P), Propylparaben (P), Rosemary Essential Oil, White Tea Essential Oil (AO).

Codebreaker: L=skin lightener, M=moisturiser, P=preservative, S=solvent AO=anti-oxidant.
 
EXPLANATIONS
Niacinamide 10%
(Vitamin B3) Helps prevent photo-immunosuppression caused by UVR.
Inhibits melanosome transfer to the keratinocytes. Also assists down-regulation of sebum production.

Ascorbyl Glucoside 2%
(Ascorbic Acid 2-Glucoside)
Promotes synthesis of collagen by fibroblasts.
Reduces fine lines and wrinkles.
Helps suppress melanin synthesis.

Undecylenoyl phenylalanine 0.5%
(UCPA)
Melanotropin inhibitor (_ MSH antagonist). Competes with melanotropin at the MC1R receptor on the melanocyte, thus inhibiting melanogenesis.

Palmitoyl Pentapeptide-3 Stimulates fibroblasts to produce collagen and elastin, resulting in reduction of the appearance of wrinkles

Sodium Hyaluronate Increases hydration in upper epidermis.
 
KNOWN CONTRAINDICATIONS/PRECAUTIONS
Pregnancy There is insufficient data about the safety of this product during pregnancy. Patients should be made aware of this at time of consultation.

Phenylketonurics This product contains phenylalanine which cannot be metabolised by PKUs and should be avoided by these patients.

STUDIES
NIACINAMIDE
In vivo studies indicate that topical niacinamide prevents photo-immunosuppression related to UVR exposure. A reduction in subsequent tumor incidence has also been reported.

In vitro and in vivo studies suggest that niacinamide may successfully inhibit melanosome transfer from the melanocyte to the keratinocyte, resulting in reduction of melanotic hyperpigmented lesions. In certain in vitro models, niacinamide achieved a 35-68% inhibition of melanosome transfer. In clinical studies of 120 women over 4 weeks, niacinamide was shown to significantly reduce epidermal hypermelanosis. 

ASCORBYL GLUCOSIDE
Ascorbyl glucoside shows analogous clinical effects to vitamin C when applied topically. This is due to the degradation of the glucoside component of the molecule in the skin by ±-glucosidase, leaving vitamin C. Ascorbyl glucoside demonstrates stimulation of collagen synthesis, as well as free radical scavenging properties. In vitro studies with cultured cells also show the ability of ascorbyl glucoside to suppress melanin production.

UNDECYLENOYL PHENYLALANINE
Research in vitro indicates that UCPA inhibits melanogenesis by acting as an _ -MSH antagonist, suppressing the melanotropin cascade, resulting in decreased tyrosinase synthesis.

PALMITOYL PENTAPEPTIDE-3
The amino acid sequence lysine-theronine-theronine-lysine-serine has been found to positively affect feedback regulation of collagen synthesis when applied topically.

niacinamide serum

PATIENT BENEFITS

NEED TO KNOW

PRODUCT USAGE

Rationale products are available from Mr Banwell's clinic please email for further details.